Endocrine Abstracts

Objective: To evaluate the main clinical characteristics and the obstetrical results of perinatal morbi-mortality of women with gestacional diabetes in our Service.Material and method: We made a descriptive study of 83 gestational diabetes patients which became a pursuit coordinated between the services of Endocrinology and Gynecology. The following main aspects were analyzed: age, toxic habits, BMI pre-gestational, first pregnancy or not, previous antec...

Objectives: To verify the results of the insulin treatment intensification in the control of Diabetes Mellitus type 1 and 2 (DM1 and DM2).Methodology: Of 100 diabetic patients (30% DM1 and 70%DM2) derived to Day Diabetes Hospital (DDH) by glycemic decompensation during year 2007 were studied, 45% women and 55% men (we excluded the debut). The average age of the patients was of 35.1 years in DM1 and 64.4 years in DM2. The Hba1c in the first visit and to t...

Objectives: To evaluate satisfaction with treatment in diabetic patients under therapy with inhaled insulin (exubera).Material and methods: Thirty-seven diabetic patients were evaluated, 27DM1 (75%) and 9DM2 (25%) that initiated treatment with Insulin inhaled (EXUBERA) between August and October 2007. Twenty-five men (69.4%) and 11 women (30.56%), between 18 and 71 years old (38.4±16.4) and with a time of evolution of diabetes between 0 and 47 years...

Objective: To study the improvement of metabolic control and patients satisfaction with glucose continuous monitoring systems (Guardian real time).Material and method: Fifteen DM1 patients studied (age: 33.8±13.40, years of evolution: 17.06±11.32) in intensive treatment (5 multidoses, 10 insulin pump) which were made one 4 days long blind monitoring Period 1 (blind period) with sensor CGMS Gold. Next another monitoring was made with a real time...

Objectives: To value the quality of life improvement and metabolic control in patients with DM1 in the 2 first years of treatment with insulin pump therapy.Material and methods: We studied 33 DM1 patients, 16 men (48.5%) and 17 women (51.5%), with average age of 34.2±12.2 and 16.3±10.21 years of disease. Pump indication was hypoglycemia in 10 (30.3%), badly metabolic control in 14 (42.4%), pregnancy in 5 (15.2%) and glycemic inestability in 4 (...

Objectives: To check possible advantages of ambulatory blood pressure monitoring (ABPM) in diagnosis and disease control respect to blood pressure conventional measurement ways.Also to study the circadian rhythm of each patient to detect higher cardiovascular risk situations.Material and methods: One hundred and nine patients were included in this study: 44% male, 56% female. ABPM were indicated in four different situations: hypert...

Background: Evidence has shown that the use of high doses of statins is associated with lower levels of LDL cholesterol and a decrease in cardiovascular events. Likewise, the use of high doses of statins may increase the risk of myopathy, elevation of liver enzymes, renal failure and cognitive alterations. We conducted a systematic review with a meta-analysis of all RCTs investigating the impact of atorvastatin and ezetimibe therapy on levels of LDL cholesterol vs high doses o...

Objective: The aim of this study is to assess the impact of continuous subcutaneous insulin infusion (CSII) via a pump for patients with type 1 diabetes mellitus (DM1) on blood glucose and metabolic control.Materials and methods: A descriptive study was performed in a cohort of patients with DM1, showing blood glucose measurements at one month, six months and one year after implantation of the CSII. In addition, we performed an intra-subject before-after...

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) is characterized by the presence of hepatic steatosis, which can progress to non-alcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. There are no licensed therapies to halt MAFLD progression, despite it is becoming the most important etiology for advanced liver disease.Aim: The aim of the study was to evaluate the therapeutic potential of inorganic nanopartic...

Introduction: Zinc transporter 8 (ZnT8) autoimmunity has been established as one of the markers for the diagnosis of type 1 diabetes (T1D) along with glutamate decarboxylase (GAD) and tyrosine phosphatase IA-2 (IA-2) antibodies. The aim of this study is to understand the status of pancreatic autoimmunity in the diagnosis of T1D, with special attention to the usefulness of ZnT8. In addition, as a second objective, we study the proposal to perform the assessment of pancreatic au...